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گت بلاگز Internet Th 17 responses are not altered by natural exposure to seasonal allergens in pollen-sensitive patients / دانلود فایل

مشخصات کلی Th 17 responses are not altered by natural exposure to seasonal allergens in pollen-sensitive patients

نویسنده کتاب (Author):

Schramm, Agata; Jasiewicz-Honkisz, Barbara; Osmenda, Grzegorz; Wilk, Grzegorz; Siedlinski, Mateusz; Sagan, Agnieszka; Matusik, Pawel; Maciag, Joanna; Sliwa, Tomasz; Czesnikiewicz-Guzik, Marta; Mikolajczyk, Tomasz

انتشارات (Publisher):

BioMed Central Ltd. 2016-10-24

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Rhinitis, Allergy, Memory cells, Cytokines      

توضیحات خلاصه (Summary):

Abstract Background Allergic rhinitis affects 10–30 % of the global population and this number is likely to increase in the forthcoming years. Moreover, it commonly co-exists with allergic asthma as a chronic allergic respiratory syndrome. While the involvement of Th 2 cells in allergy is well understood, alterations of pro-inflammatory Th 17 responses remain poorly characterized. The aim of our study was to determine whether natural seasonal allergen exposure causes changes in T cell subset characteristics in patients with allergic rhinitis and asthma. Methods Sixteen patients with allergic rhinitis/atopic asthma (9M, 7F; age 31.8 ± 12.1) and 16 healthy controls were recruited into the study (9M, 7F; age 31.2 ± 5.3). Blood samples were collected from the patients 1–3 months before pollen season (visit 1), within 7 days of the appearance of pollen/initiation of allergic symptoms (visit 2) and 2 weeks after visit 2 following the introduction of symptomatic treatment with antihistamines (visit 3). Flow cytometry was used to assess major T cell subsets (naïve, central memory, effector memory and CD45RA+ effector) and key T cell cytokine production (IFNγ, IL-17A, TNF and IL-4) using intracellular staining. Data were analyzed using repeated measures ANOVA and paired t test. Results As expected, an increase in the percentage of IL‐4+ CD4+ cells was observed during natural pollen exposure in patients with allergic respiratory syndrome. No significant changes were observed in the production of other cytokines, including Th 17 cells, which tended to be lower than in the control population but unchanged during pollen exposure. Introduction of antihistamine treatment led to only moderate changes in cytokine production from CD4 and CD8 T cells. Selective changes in CD8+ T cells were observed during natural pollen exposure including a decrease in transient cells (with features of CD45RA+ and CD45RO+ cells) and a decrease in the percentage of central memory cells in the periphera  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Schramm, Agata; Jasiewicz-Honkisz, Barbara; Osmenda, Grzegorz; Wilk, Grzegorz; Siedlinski, Mateusz; Sagan, Agnieszka; Matusik, Pawel; Maciag, Joanna; Sliwa, Tomasz; Czesnikiewicz-Guzik, Marta; Mikolajczyk, Tomasz

شناسه OCLC:979265100

Language Note:English

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