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گت بلاگز Internet Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease / دانلود فایل

مشخصات کلی Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease

نویسنده کتاب (Author):

Mikhailov, Alexander T.; Torrado, Mario

انتشارات (Publisher):

Springer 2016

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

mikhailov-at-torrado-m-myocardial-transcription-factors-in-diastolic-dysfunction-clues-for-model-systems-and-disease-heart-fail-rev-2016216783-794

موضوع (Subject):

Diastolic dysfunction       Transcription factors       MicroRNAs      

توضیحات خلاصه (Summary):

[Abstract] There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially important role of core cardio-enriched transcription factors (TFs) in the control of cardiac diastolic function in health and disease through their ability to regulate the expression of target genes involved in the process of adaptive and maladaptive cardiac remodeling. The current relevant findings on the role of a variety of such TFs (TBX5, GATA-4/6, SRF, MYOCD, NRF2, and PITX2) in cardiac diastolic dysfunction and failure are updated, emphasizing their potential as promising targets for novel treatment strategies. In turn, the new animal models described here will be key tools in determining the underlying molecular mechanisms of disease. Since diastolic dysfunction is regulated by various TFs, which are also involved in cross talk with each other, there is a need for more in-depth research from a biomedical perspective in order to establish efficient therapeutic strategies.  Read more…

ژانر / فرم:info:eu-repo/semantics/article

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Mikhailov, Alexander T.; Torrado, Mario

شناسه OCLC:979265300

Language Note:English

فهرست محتوا:1573-7322 1382-4147 http://hdl.handle.net/2183/17523


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