مشخصات کلی Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study
نویسنده کتاب (Author):
Overton, Nicola; Denning, David; Bowyer, Paul; Simpson, Angela
انتشارات (Publisher):
BioMed Central Ltd. 2016-09-27
ویرایش و نوع فایل (Edition/Format):
Downloadable article : English
منبع (Database):
عنوان ژورنال (Publication):
BioMed Central Ltd.
موضوع (Subject):
ABPA, Asthma, Genetic susceptibility, TLR3, IL4R, IL13
توضیحات خلاصه (Summary):
Abstract Background In patients with asthma, the fungus Aspergillus fumigatus can cause allergic bronchopulmonary aspergillosis (ABPA). Familial ABPA is reported, and some genetic factors have been associated with the disease, however, these are small studies (n ≤ 38) and do not explain all cases of ABPA. Methods We analysed SNPs in 95 ABPA patients, comparing frequencies to 152 atopic asthmatic and 279 healthy controls. Twenty two genes were selected from literature, and 195 tagging SNPs were analysed for genetic association with ABPA using logistic regression corrected for multiple testing. We also analysed monocyte-derived macrophage gene expression before and during co-culture with A. fumigatus . Results Seventeen ABPA-associated SNPs (ABPA v Atopic asthma) were identified. Three remained significant after correction for multiple testing; IL13 rs20541, IL4R rs3024656, TLR3 rs1879026. We also identified minor differences in macrophage gene expression responses in the ABPA group compared to the control groups. Conclusions Multiple SNPs are now associated with ABPA. Some are novel associations. These associations implicate cytokine pathways and receptors in the aberrant response to A. fumigatus and susceptibility to ABPA, providing insights into the pathogenesis of ABPA and/or its complications. We hope these results will lead to increased understanding and improved treatment and diagnostics for ABPA. Read more…
ژانر / فرم:Research
موضوع:Internet resource
نوع منبع:Internet Resource, Article
تمام نویسندگان / همکاران: Overton, Nicola; Denning, David; Bowyer, Paul; Simpson, Angela
شناسه OCLC:979265134
Language Note:English
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