کتاب مرجع WorldCat

download pdf D. Aegidii Hunnii. Theses De Abrogando Exorcismo Quas Paulo Ante Discessum ex hac vita Conscripsit ut de iis publice in Witebergensi Academia disputaretur, دانلود D. Aegidii Hunnii. Theses De Abrogando Exorcismo Quas Paulo Ante Discessum ex hac vita Conscripsit ut de iis publice in Witebergensi Academia disputaretur,Aegidius Hunnius; Egidius Hunn; Ägidius Hunnius; Aegidius Hunn; Egidius Hunnius; All authors, کتاب های Aegidius Hunnius; Egidius Hunn; Ägidius Hunnius; Aegidius Hunn; Egidius Hunnius; All authors,Erphordiae Wittelius Wolfenbüttel Herzog August Bibliothek Erfurt 1606, لیست کتاب های Erphordiae Wittelius Wolfenbüttel Herzog August Bibliothek Erfurt 1606,WorldCat, کتاب های WorldCat

گت بلاگز Internet Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study / دانلود فایل

مشخصات کلی Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study

نویسنده کتاب (Author):

Overton, Nicola; Denning, David; Bowyer, Paul; Simpson, Angela

انتشارات (Publisher):

BioMed Central Ltd. 2016-09-27

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

ABPA, Asthma, Genetic susceptibility, TLR3, IL4R, IL13      

توضیحات خلاصه (Summary):

Abstract Background In patients with asthma, the fungus Aspergillus fumigatus can cause allergic bronchopulmonary aspergillosis (ABPA). Familial ABPA is reported, and some genetic factors have been associated with the disease, however, these are small studies (n ≤ 38) and do not explain all cases of ABPA. Methods We analysed SNPs in 95 ABPA patients, comparing frequencies to 152 atopic asthmatic and 279 healthy controls. Twenty two genes were selected from literature, and 195 tagging SNPs were analysed for genetic association with ABPA using logistic regression corrected for multiple testing. We also analysed monocyte-derived macrophage gene expression before and during co-culture with A. fumigatus . Results Seventeen ABPA-associated SNPs (ABPA v Atopic asthma) were identified. Three remained significant after correction for multiple testing; IL13 rs20541, IL4R rs3024656, TLR3 rs1879026. We also identified minor differences in macrophage gene expression responses in the ABPA group compared to the control groups. Conclusions Multiple SNPs are now associated with ABPA. Some are novel associations. These associations implicate cytokine pathways and receptors in the aberrant response to A. fumigatus and susceptibility to ABPA, providing insights into the pathogenesis of ABPA and/or its complications. We hope these results will lead to increased understanding and improved treatment and diagnostics for ABPA.  Read more…

ژانر / فرم:Research

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Overton, Nicola; Denning, David; Bowyer, Paul; Simpson, Angela

شناسه OCLC:979265134

Language Note:English

دانلود


دانلود فایل ها

نویسنده : getblogs