مشخصات کلی FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle

نویسنده کتاب (Author):

Varela-Rodríguez, BM; Pena-Bello, Lara; Juiz-Valiña, Paula; Vidal Bretal, Beatriz; Cordido Carballido, Fernando; Sangiao-Alvarellos, Susana

انتشارات (Publisher):

Nature 2016-07-19

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

Varela Rodríguez BM, Pena-Bello L, Juiz-Valiña P, et al. FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle. Sci Rep [Internet]. 2016;6,29898

موضوع (Subject):

Multihormonal system disorders       Obesity      

توضیحات خلاصه (Summary):

[Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum irisin and FNDC5 mRNA expression levels, we evaluated plasma irisin levels and FNDC5 gene expression in the hypothalamus, gastrocnemius muscle and different depots of adipose tissue in models of altered metabolism. In normal rats, blood irisin levels diminished after 48-h fast and with leptin, insulin and alloxan treatments, and serum irisin concentrations increased in diabetic rats after insulin treatment and acute treatments of irisin increased blood insulin levels. No changes were observed during long-term experiments with different diets. We suggested that levels of circulating irisin are the result of the sum of the irisin produced by different depots of adipose tissue and skeletal muscle. This study shows for the first time that there are differences in FNDC5 expression depending on white adipose tissue depots. Moreover, a considerable decrease in visceral and epididymal adipose tissue depots correlated with increased FNDC5 mRNA expression levels, probably in an attempt to compensate the decrease that occurs in their mass. Hypothalamic FNDC5 expression did not change for any of the tested diets but increased with leptin, insulin and metformin treatments suggesting that the regulation of central and peripheral FNDC5/irisin expression and functions are different.  Read more…

ژانر / فرم:info:eu-repo/semantics/article

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Varela-Rodríguez, BM; Pena-Bello, Lara; Juiz-Valiña, Paula; Vidal Bretal, Beatriz; Cordido Carballido, Fernando; Sangiao-Alvarellos, Susana

شناسه OCLC:979265138

Language Note:English

فهرست محتوا:http://hdl.handle.net/2183/18278

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